Author: Benjamin Bonavida (Editor), Salem Chouaib (Editor) Full Title: Resistance Of Cancer Cells To CTL-Mediated Immunotherapy Publisher: Springer; 2015 edition (June 21, 2015) Year: 2015 ISBN-13: 9783319178073 (978-3-319-17807-3), 9783319178066 (978-3-319-17806-6), 9783319380674 (978-3-319-38067-4) ISBN-10: 3319178075, 3319178067, 3319380672 Pages: 353 Language: English Genre: Biomedical Sciences: Cancer Research File type: PDF (True) Quality: 10/10 Price: 155.99 € This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more. ------------- Our members see more. Join us!
