Adis | Efflux-Mediated Antimicrobial Resistance In Bacteria: Mechanisms, Regulation And Clinical Implications (2016 EN)

Author: Xian-Zhi Li (Editor), Christopher A. Elkins (Editor), Helen I. Zgurskaya (Editor)
Full Title: Efflux-Mediated Antimicrobial Resistance In Bacteria: Mechanisms, Regulation And Clinical Implications
Publisher: Adis; 1st ed. 2016 edition (November 10, 2016)
Year: 2016
ISBN-13: 9783319396583 (978-3-319-39658-3), 9783319396569 (978-3-319-39656-9)
ISBN-10: 3319396587, 3319396560
Pages: 848
Language: English
Genre: Medical Microbiology
File type: PDF (True)
Quality: 10/10
Price: 274.56 €


This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.

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