SPRI | Chromatin Regulation Of Early Embryonic Lineage Specification (2018 EN)

Author:Jason Knott (Editor), Keith Latham (Editor)
Full Title: Chromatin Regulation Of Early Embryonic Lineage Specification
Publisher: Springer; 1st ed. 2018 edition (November 25, 2017)
Year: 2018
ISBN-13: 9783319631875 (978-3-319-63187-5), 9783319631868 (978-3-319-63186-8)
ISBN-10: 331963187X, 3319631861
Pages: 78
Language: English
Genre: Biomedical Sciences: Human Genetics
File type: EPUB (True), PDF (True)
Quality: 10/10
Price: 117.69 €


Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.

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