SPRI | Phosphodiesterases: CNS Functions And Diseases (2017 EN)

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  1. Kanka

    Kanka Well-Known Member Loyal User

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    Author: Hanting Zhang (Editor), Ying Xu (Editor), James M O'Donnel (Editor)
    Full Title: Phosphodiesterases: CNS Functions And Diseases
    Publisher: Springer; 1st ed. 2017 edition (October 26, 2017)
    Year: 2017
    ISBN-13: 9783319588117 (978-3-319-58811-7), 9783319588094 (978-3-319-58809-4)
    ISBN-10: 3319588117, 3319588095
    Pages: 471
    Language: English
    Genre: Biomedical Sciences: Neuroscience
    File type: PDF (True)
    Quality: 10/10
    Price: 213.99 €


    PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

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