Author: Itaru Kojima (Editor) Full Title: Glucose-Sensing Receptor In Pancreatic Beta-Cells Publisher: Springer; 1st ed. 2018 edition (July 1, 2018) Year: 2018 ISBN-13: 9789811300028 (978-981-13-0002-8), 9789811300011 (978-981-13-0001-1) ISBN-10: 981130002X, 9811300011 Pages: 71 Language: English Genre: Biomedical Sciences: Human Physiology File type: EPUB (True), PDF (True) Quality: 10/10 Price: 139.09 € Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.” This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. ------------- Damnant quod non intellegunt!