SPRI | Progranulin And Central Nervous System Disorders (2019 EN)

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  1. Kanka

    Kanka Well-Known Member Loyal User

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    Author: Hideaki Hara (Editor), Masato Hosokawa (Editor), Shinsuke Nakamura (Editor), Takayoshi Shimohata (Editor), Masugi Nishihara (Editor)
    Full Title: Progranulin And Central Nervous System Disorders
    Publisher: Springer; 1st ed. 2019 edition (March 25, 2019)
    Year: 2019
    ISBN-13: 9789811361869 (978-981-13-6186-9), 9789811361852 (978-981-13-6185-2)
    ISBN-10: 981136186X, 9811361851
    Pages: 183
    Language: English
    Genre: Biomedical Sciences: Human Genetics
    File type: EPUB (True), PDF (True)
    Quality: 10/10
    Price: 160.49 €


    This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

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