SPRI | Sigma Receptors: Their Role In Disease And As Therapeutic Targets (2017 EN)

Author: Sylvia B. Smith (Editor), Tsung-Ping Su (Editor)
Full Title: Sigma Receptors: Their Role In Disease And As Therapeutic Targets
Publisher: Springer; 1st ed. 2017 edition (27 Mar. 2017)
Year: 2017
ISBN-13: 9783319501741 (978-3-319-50174-1), 9783319501727 (978-3-319-50172-7)
ISBN-10: 3319501747, 3319501720
Pages: 312
Language: English
Genre: Biomedical Sciences
File type: PDF (True)
Quality: 10/10
Price: 181.89 €


Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

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